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Weight loss phentermine pills can't be as effective. It's not just an issue of quantity; it's about quality. In an editorial on Dec. 12 for JAMA Internal Medicine, a team of researchers from the National Institute on Drug Abuse (NIDA) concluded that, although the findings of previous reviews and meta-analyses the use of medications for weight loss have been conflicting, there was no compelling evidence for or against the use of antipsychotic medications for this use. Antipsychotic medications are used for an estimated 40%–50% of patients treated with bariatric surgery. The authors wrote that in a survey of bariatric surgeons performed by the National Health and Nutrition Examination Survey in 2007, 67% of respondents reported prescribing antipsychotic medications at least occasionally. For those patients who don't respond to these treatments, the team wrote: [T]here is insufficient evidence that an antipsychotic, at the doses used for weight loss, is more effective than placebo in improving subsequent weight loss. There are also indications that patients may suffer an increased risk of adverse effects from antipsychotics, including weight gain, sedation, and gastrointestinal disturbances (5, 6). We have no evidence to suggest that patients receiving an antipsychotic do not achieve significant weight loss compared with those who do not receive such therapy (5, 6). The researchers also noted that results of a recent review the literature on use of antipsychotic medication for weight loss showed mixed results (7). A few studies have shown benefits; most of these have been short term studies in patients with a weight loss and/or maintenance goal. There was no evidence that such drugs work better than placebos in patients without a weight loss goal (7). In Diclofenac sodium to buy an accompanying editorial, David B. Allison, PhD, from the department of medicine and health promotion at the University of Alabama Birmingham wrote: Given the weight, mood and metabolic effects of antipsychotic medications, which, like all medications in the management of mental and physical illness, may be useful in some patients but have risks and benefits, the appropriate use of these medications in bariatric surgery patients remains contention. In a commentary on the same journal's website, University of Texas Southwestern Medical Center's David J. Kramer, MD, and James W. Breland, MD said they were "disappointed" by the new NIDA paper: We have no idea why some Valsartan doc generici 80mg patients are more sensitive to the positive effects of antipsychotic drugs and why others are not. given that we don't know, it is unwise to prescribe antipsychotic medication for weight loss. There is some indication that antipsychotics are useful for reducing appetite in some obese patients, but there needs to be much more research, especially of long-term effects. But other experts in the area disagreed, and noted that the NIDA other authors were "not qualified to speak on these issues of efficacy." The American Diabetes Assn. wrote in an accompanying editorial that while there's no evidence antipsychotic medications are more effective than placebo at treating diabetes-related weight changes, that doesn't mean they should not be used to treat this disease, especially when diet and exercise alone can't treat it (8). In a statement, the Diabetes Research and Obesity Society (Drexel University in Philadelphia/Drexel Philadelphia) wrote: We believe that there is no justification to deny diabetes individuals whose blood glucose levels are out of control because they are overweight. The use of antipsychotic medication for weight loss in obesity is not supported by current evidence. In light of the new NIDA review and other reviews in recent years, there may be more to know before a decision should be made to use medication for the treatment of obesity. Reference 1. NIDA. (2013). Treatment of obesity in adult and pediatric patients with antipsychotic medication. Bethesda, MD: National Institute of Mental Health. 2. Kramer J, Breland JA, Allison DP. (2010). Adverse events in a randomized trial of antipsychotic medication for the treatment of obesity. Ann. Intern. Med., 151, atorvastatin ratiopharm 20 mg filmtabletten 805–11. doi:10.7326/M17-039.3815 PubMed Abstract | CrossRef Full Text Google Scholar 3. Schmitz M, Czapkowski Leitzmann et al. (2012). Long-term safety and efficacy of olanzapine as adjunct to diet in a group of obese patients with schizophrenia. Psychoneuroendocrinology, 38, 739-45. doi:10.1016/j.psyneuen.2012.08.018 PubMed Abstract | CrossRef Full Text Google Scholar 4. NIDA. (2016). A brief note on antipsychotic drugs for weight loss and maintenance: a scientific statement from the National.

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